Title:

Convolutional Neural Networks for C. Elegans Muscle Age Classification Using Only Self-learned Features, Journal of Telecommunications and Information Technology, 2022, nr 4

Creator:

Dzwonkowski, Mariusz ; Czaplewski, Bartosz ; Panas, Damian

Subject and Keywords:

machine learning ; deep learning ; C. elegans muscle aging ; convolutional neural networks ; biomedical imaging

Description:

Nematodes Caenorhabditis elegans (C. elegans) have been used as model organisms in a wide variety of biological studies, especially those intended to obtain a better understanding of aging and age-associated diseases. This paper focuses on automating the analysis of C. elegans imagery to classify the muscle age of nematodes based on the known and well established IICBU dataset. Unlike many modern classification methods, the proposed approach relies on deep learning techniques, specifically on convolutional neural networks (CNNs), to solve the problem and achieve high classification accuracy by focusing on non-handcrafted self-learned features. Various networks known from the ImageNet Large Scale Visual Recognition Challenge (ILSVRC) have been investigated and adapted for the purposes of the C. elegans muscle aging dataset by applying transfer learning and data augmentation techniques. The proposed approach of unfreezing different numbers of convolutional layers at the feature extraction stage and introducing different structures of newly trained fully connected layers at the classification stage, enable to better fine-tune the selected networks. The adjusted CNNs, as featured in this paper, have been compared with other state-of-art methods. In anti-aging drug research, the proposed CNNs would serve as a very fast and effective age determination method, thus leading to reductions in time and costs of laboratory research.

Publisher:

Instytut Łączności - Państwowy Instytut Badawczy

Date:

2022, nr 4

Resource Type:

artykuł

Format:

application/pdf

Resource Identifier:

ISSN 1509-4553, on-line: ISSN 1899-8852

DOI:

10.26636/jtit.2022.165322

eISSN:

1899-8852

Source:

Journal of Telecommunications and Information Technology

Language:

ang

Rights Management:

Biblioteka Naukowa Instytutu Łączności