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Title: Evolutionary Algorithm that Designs the DNA Synthesis Procedure, Journal of Telecommunications and Information Technology, 2011, nr 4

Creator:

Nowak, Robert ; Michalak, Maciej

Date:

2011, nr 4

Resource Type:

artykuł

Description:

Chemical synthesis of nucleotide chains is very erroneous for long sequences. Often a gene is constructed from short fragments joined with the use of complementary helper chains. The number of possible potential solutions for a long gene synthesis is very large, therefore a fast automated search is required. In the presented approach a modified method of long DNA construction is proposed. A computer program that searches for an optimal solution in the space of potential synthesis methods has been developed. This software uses an evolutionary algorithm for global optimization and a hill- climbing algorithm for local optimization. The long DNA construction method was tested on random sequences. The results are very promising. The next step is to perform experiments in a biotechnological wet laboratory involving DNA strand synthesis using the method designed by the presented software.

Publisher:

Instytut Łączności - Państwowy Instytut Badawczy, Warszawa

Format:

application/pdf

Resource Identifier:

oai:bc.itl.waw.pl:1199 ; ISSN 1509-4553, on-line: ISSN 1899-8852

DOI:

10.26636/jtit.2011.4.1177

ISSN:

1509-4553

eISSN:

1899-8852

Source:

Journal of Telecommunications and Information Technology

Language:

ang

Rights Management:

Biblioteka Naukowa Instytutu Łączności

Subject and keywords:

bioinformatics gene synthesis optimum searching

Object collections:

Last modified:

Aug 29, 2024

In our library since:

May 23, 2013

Number of object content hits:

172

All available object's versions:

https://bc.itl.waw.pl/publication/1504

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Edition name Date
Michalak, Maciej; Nowak, Robert, Evolutionary Algorithm that Designs the DNA Synthesis Procedure, Journal of Telecommunications and Information Technology, 2011, nr 4 Aug 29, 2024

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Instytut Łączności – Państwowy Instytut Badawczy ul. Szachowa 1 04-894 Warszawa

Phone

(+48) 5128 696

E-Mail

biblioteka@il-pib.pl

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